Abstract
Tissue engineering is a multidisciplinary field that aims to restore, maintain, and improve tissue performance by producing functional tissue constructs. The three major domains of tissue engineering are isolated cells or stem cells, biomaterial scaffolds and biomolecules. Hydrogels are commonly studied as scaffold materials for tissue regeneration due to its unique characteristics, i.e., excellent water absorbing and swelling capacity, tunable mechanical properties, porous structure, biocompatibility, biodegradability, flexibility similar to natural tissues and responsive to various stimuli (e.g., changes in pH, humidity, light and temperature). In the past decades, additive manufacturing (bioprinting) has emerged as a powerful technology in tissue and organ regeneration where it incorporates hydrogels as functional scaffolds. Various hydrogel-based delivery systems have also been developed in search of ideal scaffold for tissue engineering. In view of the potential of hydrogels in the field of tissue engineering, herein presents a review focusing on application of hydrogels for drug delivery in tissue engineering as well as additive manufacturing.
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